MALVERN ZETASIZER NANO-ZS

GENERAL INFORMATION | STANDARD OPERATING PROCEDURE

Location: Havemeyer 544

The Malvern Zetasizer Nano-ZS is a dynamic light scattering (DLS) instrument used to measure particle size, molecular weight, and zeta potential of dispersed particles and molecules in liquid suspension. This system uses laser light scattering to analyze the Brownian motion of particles, determining hydrodynamic diameter for particles ranging from sub-nanometer to several microns. The instrument employs non-invasive backscatter (NIBS) technology with a 633 nm laser and 173° scattering angle for high sensitivity across a wide concentration range. Zeta potential measurements are performed using laser Doppler micro-electrophoresis, providing information about surface charge and colloidal stability. Dynamic light scattering measurements are possible with samples as small as 12 μL, while zeta potential measurements require approximately 0.5 mL.

The system is commonly used for characterizing organic and aqueous colloids, nanoparticles, and proteins. Applications include quality control of nanomaterials, formulation development in pharmaceuticals and cosmetics, stability studies of colloidal dispersions, protein aggregation and molecular weight analysis, and assessment of surface modifications. Temperature control enables measurements across a range of conditions to study temperature-dependent behavior, making it suitable for both research and routine analysis.

For more information please contact Dr. Luca Telesca.